Objectives : The present study has been undertaken to investigate the effects of Chungajihwangtang on osteoporosis in ovariectomized rats.
Methods : In this experiment, the rats were ovariectomized. These rats were administered water extract of Chungajihwangtang. The levels of bone mineral density, ALP, calcium, phosphorus in serum, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured.
Results : The bone mineral density of spinal bone, femoral bone and fibular-tibial bone was increased in comparison with those of OVX group in Chungajihwangtang treated group, and the change of BMD of spinal bone had statistical significance. The levels of serum phosphorus showed significant increase in comparison with those of OVX group at 8 weeks in Chungajihwangtang treated group.
The levels of femoral and fibula-tibial calcium and phosphorus showed significant increase in comparison with those of OVX group in Chungqiihwangtang treated group.
The levels of body weight showed decrease in comparison with those of OVX group in Chungajihwangtang treated group, but this result had not statistical significance.
The levels of uterus weight showed increase in comparison with those of OVX group in Chungajihwangtang treated group, but this result had not statistical significance.
Conclusions : Reviewing these experimetal results, it appears that Chungajihwang- tang was effective on osteoporosis. And further study on Chungajihwang-tang should be conducted to illustrate in depth the curing osteoporosis.
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